Prior to treating children and adults with CNS stimulants, including Quillivant XR, assess for the risk of abuse as well as the presence of cardiac disease (ie, perform a careful history, family history of sudden death or ventricular arrhythmia, and physical exam) and risk for abuse. Starting dose is 20 mg which can be titrated up or down, weekly, in increments of 10 to 20 mg up to a maximum daily dose of 60 mg. Reduce dosage if a paradoxical aggravation of symptoms or other adverse events occur. Discontinue if intolerable side effects develop or after 1 month if improvement is not seen after appropriate dose adjustments.